A couple of years ago, the Family Physician set me up with a 30-day trial ($10 out of pocket) of something called Invokana (canagliflozin). After a couple of doses, I felt terribly queasy, and abandoned the drug; after 15 years or so, the doctor knows when I’m giving up on something, and that was the end of that.
People with diabetes are already at risk of having lower limbs amputated because of circulatory and nerve damage that the disease does over time. However, in two clinical trials of the drug canagliflozin, marketed as Invokana, Invokamet, and Invokamet XR, patients taking the drug were twice as likely to need amputations.
Most of the amputations were of toes or the middle of the foot, but some patients needed their entire foot or leg removed, sometimes even above the knee.
I know only one other person who takes this stuff; I’m debating whether I should shove this link under his nose, or wait for the Black Box Warning to show up on the next package.
Addendum: I told him directly.