Just to let you know, this has nothing whatever to do with earthquakes.
Archive for Ease and Disease
In late October, Sarah Sloan Macleod put up a video called “The Realest I’ve Ever Been About My Depression.” It was frightening in spots, and some of those spots were entirely too familiar to me:
A week later, things got realer:
Both of these contain occasional rough words, so watch where you play them.
Off to the ER I went. After a wait of 4 hours, I was brought into a procedure room, where I was examined other doctors brought in, and was told immediately that I’d be scheduled for surgery. They had me in a ward within 20 minutes, and began pumping me full of anti-biotics. The next morning, they had me prepped and the anesthesiologist asked me if I would prefer to be sedated with a mixture of ketamine and other fine drugs, or epidural. I’ve had an epidural before. That did not go well. IV cocktail it is.
There followed the actual surgery, and then:
I was made to stay another night for more antibiotics being pumped in while they looked after me. The next day, the nurses did a repack and bandaging. From there, it was a matter of getting me scripts and arranging for a care nurse that will come to my home everyday for the next month and deal with dressings until it’s no longer needed.
His one out-of-pocket expense was for those scripts:
Ten antibiotic, ten painkillers, 100 acetaminophen. Twenty bucks American. About what you’d fork over for a single antibiotic in the States, if you’re lucky.
Just follow the otherwise-empty arrow:
This is just the silliest drug packaging, there's literally nothing in that arrow and two (!) tablets come in the box. pic.twitter.com/B5MJf3xabP
— Signe Dean (@nevertoocurious) October 24, 2017
A box of two? Wow.
Wikipedia semi-helpfully points out that “[i]n the United States, it is available only by medical prescription (and is frequently limited, without prior authorization, to a quantity of nine in a 30-day period).” A quantity of nine, per Drugs.com, runs $92.52. To someone with a migraine, a condition for which this drug is indicated, ten bucks and change for a single tab is probably worth it. Maybe the two-tab version is intended to get you through a particularly bad weekend.
Oh, yeah, it’s the same old Panther-bodied Ford Crown Victoria Police Interceptor you’ve known and feared for years, but this one is for a cause:
The idea behind the pink car came from Chris Lee who is the owner of Shift Designs in Dothan.
After serving the Dothan community for eight years, he wanted a way to give back to the community that has been so great to him and his team.
So, he volunteered to wrap a patrol car in honor of Breast Cancer Awareness month.
With the help of Avery Dennison Graphic Solutions, a premiere vinyl and wrap company, they were able to have the supplies donated for the cause.
Pretty spiffy, though the standard Ford dog-dish hubcaps look even tinier than usual.
In the event of something happening to me,
There is someone I should probably go to see:
Presumably very good at helping people Stay Alive… pic.twitter.com/JzX1fW7Upe
— Joe Bonsall (@joebonsall) October 12, 2017
Please tell me this is not the result of someone starting a joke.
I ran this little poll on Twitter, and I am not heartened, if not surprised, by the results:
O frabjous day! As of 1/1/18. my health insurance is kaput. How much more am I going to have to fork over?
— Charles G Hill (@dustbury) October 2, 2017
CFI Care (not its real initials) isn’t dropping the group, necessarily; but the group policy we had is being discontinued, to be replaced by God Knows What. And God, presumably wisely, is keeping His mouth shut.
She set her computer on her lap and crossed her legs. For a moment I wondered how she was going to type like that.
“So how do you feel right this minute?” she asked.
This whole medical insurance debate is complete and utter horseshit. (Heh, my new catch phrase.) What we need is real information, but we’re not getting it. It might be out there, but digging it out would be a lot of work, and why bother? Nobody in power is listening, they are all listening to each other trying to score political points by telling bullshit stories.
Our healthcare system is built on a fantasy, a fantasy that is carefully nurtured by everyone with a financial interest, like doctors, lawyers, insurance executives and media moguls. This fantasy has doctors curing all diseases, patients recovering fully and leading happy, productive lives. Oh, that happens occasionally, and for common afflictions that are well understood, it might even be the norm. But the more people you have, the more variation you have and the more obscure, inscrutable diseases show up. Life is a terminal disease. People spend their lives trying to be happy. They should spend their time getting ready to die.
Health care is a trillion dollar business in this country. All those people who are engaged in the debate over insurance are just trying to influence the trajectory of that money so that more of the random spray that emanates from such a powerful stream will land on them and make them rich. Because even a single droplet from that trillion dollar stream is worth a million bucks.
I take issue with that “getting ready to die” business; I mean, with the death rate seemingly frozen at 100 percent, everyone’s going to go through that routine at least once, if only for a few seconds, and there are enough differences among us to insure that a Standard Preparation Routine would fall under the general heading of “one size fits none.”
That said, there apparently exists no sum of money so small that someone won’t try to get a piece of it: ask the guy who buys 10,000 shares of Consolidated Veeblefetzer at $37.19 and sells them in three minutes for $37.20.
It’s named for the reeler mouse, a mutant with really terrible motor skills.
Reelin is a complicated chemical found floating around in your body. Near as I can tell, it has some influence over the central nervous system. I got onto this from a Reddit link to a Wikipedia passage about schizophrenia, one of my least favorite diseases.
Reelin has been suggested to be implicated in pathogenesis of several brain diseases. The expression of the protein has been found to be significantly lower in schizophrenia and psychotic bipolar disorder, but the cause of this observation remains uncertain as studies show that psychotropic medication itself affects reelin expression. Moreover, epigenetic hypotheses aimed at explaining the changed levels of reelin expression are controversial. Total lack of reelin causes a form of lissencephaly. Reelin may also play a role in Alzheimer’s disease, temporal lobe epilepsy and autism.
A mere 3,461 amino acids go into this stuff, which sort of reminds me of why I never became a chemist:
I’m not very good at chemistry. Oh, I understand the basics well enough, water is made of two hydrogen atoms and one oxygen atom, but once you get past the basics there is an endless profusion of chemical compounds and I quickly become lost. It’s almost like the English language, you can stick words, or atoms, together in a limitless number of ways. If you use it every day, those combinations will become familiar to you, like the books you have read. But if you don’t immerse yourself in this sea of arcane knowledge it will always be gibberish.
And even then, I suspect, you’re always going to be at least somewhat behind the times.
Integris Health, the biggest hospital in town, and Blue Cross/Blue Shield, the only insurer left in the federal insurance exchange for this state, were on the outs. Shortly before the pertinent contracts ran out, they kissed and made up.
Yesterday, I got a letter from Integris, signed by CEO Bruce Lawrence, to this effect:
I sincerely apologize for any frustration, inconvenience or concern you experienced during these contract negotiations. Our intent was to negotiate an agreement that would allow Integris to continue to offer the critical services not offered elsewhere in Oklahoma … service you or a family member may need some day. Although we tried to be as reassuring as possible during this process, we recognize the uncertainty the negotiations may have caused you.
Well, yeah, considering the war of words was fought largely in local media, with FUD as ammunition. To bolster that impression, here’s Mr Lawrence again:
I truly appreciate those of you who made phone calls to Blue Cross on our behalf; your efforts made a significant impact.
Of course, this has been the guiding principle of high-zoot health care since the invention of the phrase “Ask your doctor if [hyperexpensive new drug] is right for you.”
Our focus is on gentlemen who have been dealt a tough hand in life. In particular, we raise funds for research into prostate cancer and mental health programs as part of our mission to support men’s health globally. These funds are invested by our partners the Movember Foundation, the world’s largest men’s health organisation.
Based in Australia, Movember, whose signature event involves the growing of mustaches, has raised over half a billion dollars in 21 countries.
I’ve signed up for the Distinguished Gentleman’s Ride next month. It’s a great charity masquerading as a bunch of dickheads wearing suits on dorky motorcycles. I’m planning on wearing a Hickey Freeman pinstripe and riding my Honda CB1100. If you want to throw five bucks towards the cause, you can do it here.
I have done so.
Those of you who hate my guts can be reassured by the fact that it’s almost certain to rain this time of the year and that I’ll basically be spending two hours wrapped in three layers of soaking-wet wool. There’s also a reasonable chance that one of these hipsters who can barely ride a motorcycle by themselves, let alone in a group, will run into me and cut off my leg.
Hmmm. Maybe five bucks isn’t enough.
The Food and Drug Administration on Wednesday approved a futuristic new approach to treating cancer, clearing a Novartis therapy that has produced unprecedented results in patients with a rare and deadly cancer. The price tag: $475,000 for a course of treatment.
That sounds staggering to many patients — but it’s far less than analysts expected.
The therapy, called a CAR-T, is made by harvesting patients’ white blood cells and rewiring them to home in on tumors. Novartis’s product is the first CAR-T therapy to come before the FDA, leading a pack of novel treatments that promise to change the standard of care for certain aggressive blood cancers.
Novartis’s therapy is approved to treat children and young adults with relapsed acute lymphoblastic leukemia. It will be marketed as Kymriah.
The generic name of this stuff is “Tisagenlecleucel.” Now, about that price tag:
Novartis picked the $475,000 price tag in an effort to balance patient access to Kymriah while giving the company a return on its investment, said Bruno Strigini, Novartis’s head of oncology, in a conference call Wednesday. The cost is below Wall Street analyst expectations, which reached as high as $750,000 for a dose. And it’s considerably cheaper than the roughly $700,000 price tag that U.K. regulators said would be fair considering Kymriah’s potential benefits.
For one dose?
In a clinical trial, a single dose of Kymriah left 83 percent of participants cancer-free after three months, results oncologists have hailed as a major advance for patients with few other options. The most frequent side effect was an inflammatory storm called cytokine release syndrome, a reaction to CAR-T that can prove fatal in some patients but is commonly controlled with immunosuppressant drugs.
Deaths due to cytokine release syndrome with OKT3 (muromonab-CD3) have been reported, and it can cause life-threatening pulmonary edema if the patient is fluid overloaded. However, if treated appropriately it is usually not dangerous, just extremely unpleasant for the patient.
I bet it is. And it’s probably unpleasant for one’s insurance carrier as well.
(Via Joanna Blackhart.)
The very first line of the Easybeats’ classic hit “Friday On My Mind” pretty much says it all: Monday morning has little to recommend it. And as Zoe Thomson explains, if you’re fighting a mental illness, “little” dwindles to imperceptibility:
The alarm goes off and I’m tossing and turning, feeling weighted by the duvet but also uncomfortable, not feeling well rested in the slightest. “5 more minutes” I think to myself, a pit of dread sitting nervously in my stomach, but why? It’s another day. I don’t snooze my alarm — I stop it. I hope that I sleep in far too late and I have no choice but to jump out of bed and get out the door. I haven’t got it in me today, just like every other day. The dread fills my stomach until I can no longer only acknowledge it — it’s the only thing I can think about. I feel sick. I feel ill. Maybe I could use that? No, I can’t. I feel so groggy and not very well put together and I wonder how I’m going to do this for another 5 days.
My own issues are more or less out in the open, so you probably won’t be too surprised to hear that my own Monday-morning dread begins about 9 pm Sunday. Bedtime is still two hours away, and I wonder how much, if any, sleep I’m going to get during the seven and a half hours allotted. I’m certainly wide awake that Sunday evening. (The weekly roundup of strange search-engine queries? I did that early Sunday afternoon. Maybe even late Saturday night.) Somehow, I’ve managed to sleep through the alarm only two or three times in the past year. I remember that my work week has shrunk by about five hours since then; and then I recall that what I really want is to have it shrink by about five days. But that’s not happening any time soon.
In fact, the weirdest aspect of all this is that the pertinent song by The Cure is decidedly happier in tone, at least at the beginning:
And here we are, somehow, at Friday, looking forward to the weekend.
What are the chances of it becoming like Youtube?
Update: What if i told you i have that “hook” store somewhere in my main computer? …
Now what would the chances be?
Update 2: What if i could even use that “hook” on other software i could create. Like maybe another Social Website like Facebook or Twitter or Snapchat. Yeah i could even use that “hook” on Theaters.
Update 3: Imagine the fortune i would have. Yes … i am not lying. I have the software and source code. I created it all by myself.
Problem is i don’t know where to even start. I know i would need investors. Then i would need to settle out somewhere. I live in Texas but i want to move out to California. Yeah. To where every Tech company goes. Silicon Valley. Wonder if Facebook or Google will come down chasing me. You know. To buy my software. I don’t want to sell it. I want to use it and make it grow.
Update 4: I could even use it on Holograms.
0_0 … i could make it to be the richest man in the world.
They probably know already. Or the Illumanti. Knows. They send me a message on my email. I never share my personal email. THEY SOMEHOW send me an email.
They know it could be worth Trillions of dollars.
Update 5: I don’t want the fame i just want the money and the company i am simple man.
Actually, they wanted you to learn how to spell “Illuminati” correctly, you dimwit.
Occasionally you hear of some product or other being recalled because of an FDA order. It’s been a while, though, since I heard of the entire line of a manufacturer being ordered off the shelves:
The U.S. Food and Drug Administration is advising consumers and health care professionals not to use any liquid drug or dietary supplement products manufactured by PharmaTech LLC of Davie, Florida, and labeled by Rugby Laboratories, Major Pharmaceuticals and Leader Brands, due to potential contamination with the bacteria Burkholderia cepacia and the risk for severe patient infection.
The drug and dietary supplement products made by PharmaTech include liquid docusate sodium drugs (stool softeners), as well as various dietary supplements including liquid vitamin D drops and liquid multivitamins marketed for infants and children.
“B. cepacia poses a serious threat to vulnerable patients, including infants and young children who still have developing immune systems,” said FDA Commissioner Scott Gottlieb, M.D. “These products were distributed nationwide to retailers, health care facilities, pharmacies and sold online — making it important that parents, patients and health care providers be made aware of the potential risk and immediately stop using these products.”
According to the Centers for Disease Control and Prevention (CDC), B. cepacia poses the greatest threat to hospitalized patients, critically ill patients and people with health problems such as weakened immune systems and chronic lung diseases. The symptoms of B. cepacia infections vary widely from none at all to serious respiratory infections. It can spread from person-to-person by direct contact and is often resistant to common antibiotics.
Burkholderia cepacia is an opportunistic human pathogen that most often causes pneumonia in immunocompromised individuals with underlying lung disease (such as cystic fibrosis or chronic granulomatous disease). Patients with sickle-cell haemoglobinopathies are also at risk. The species also attacks young onion and tobacco plants, as well as displaying a remarkable ability to digest oil.
The FDA announcement contains brand names and descriptions of the recalled drugs.
(Via Glenn Reynolds.)
News Item: Still no deal between Integris and Blue Cross and Blue Shield. Without it more than 150,000 Blue Cross Blue Shield members may have to find a new doctor October 24th and Integris will be out of network August 31st.
Newspaper ad, August 9th:
The war of words escalates, as it seemingly always does.
A bill from the Community Hospital of Beloit, Kansas, for a patient with appendicitis:
Adjusting for inflation since 1932 the cost in today’s dollars would be $2,265.49.
This does not include the surgeon’s fee.
Not that you can expect to pay anything like that to today’s Mitchell County Hospital Health Systems. And there’s this, from five years ago:
[T]he charges for treating appendicitis at hospitals in California ranged from about $1,500 to more than $182,000.
Moreover, patients usually have no idea what their bill will be when they enter the hospital, said study researcher Dr. Renee Hsia, an assistant professor of emergency medicine at the University of California, San Francisco. And those who provide care are usually unaware of how much their treatment recommendations cost, Hsia said.
What’s changed since then? Only the prices, which are higher.
In which I press my luck by announcing that for the moment, the worst of my ongoing insomnia seems to have subsided a bit, though I still need all the help I can get.
Once upon a time, I inhaled a few particles of what was then called “Nestlé’s Quik.” (It has since been truncated to “Nesquik,” which to me sounds too much like “Bisquick.”) It was nothing like this:
It may sound like one of Willy Wonka’s failed inventions (three course dinner gum, anyone?), but you can now purchase a “snortable” chocolate powder as an all-natural way to get high.
Coco Loko, the latest product from Orlando-based Legal Lean, boasts an intimidating mix of cacao powder, gingko biloba, taurine, and guarana (ingredients most frequently found in energy drinks). The effects are said to be a 30-minute to one hour buzz that is “almost like an energy-drink feeling, like you’re euphoric but also motivated to get things done.”
Yeah, that would definitely intimidate me. But it’s just one more data point to support the theory that chocolate is uniquely useful.
(Via American Digest.)
If social media are to be believed — and I’m not saying they are — multiple handbaskets are being readied for our trip to the hot nether regions.
The Daily Brief happened upon this comment, and maybe it explains things:
I have often considered that there are a lot more people who have degrees of mental illness out there than we generally realise. Most of the time they can function relatively OK, if surrounded by good people who try and keep them on the path of sanity, however if they are steered in the wrong direction — their inherent bias towards fantasy thinking will mean they go down the wormhole when a more sane person who stop and think “Hang on a minute here!” I think the reason we are seeing more of the misdirection now is the internet — it’s all there on everyone’s Facebook and Twitter feeds, and 100% accessible to all, whereas in the past such people would probably never have been exposed to such twisted thinking. Now they are, and they lack the critical faculties to determine what is true and what is false.
For all I know, there are still people out there who believe that you can’t say something untrue on television, because of federal law or the Seal of Good Practice or whatever. God forbid they should get caught up in the 24-hour cable news cycle.
No, not mine. But I suspect I’d probably have a similar complaint:
How did people manage in the bad old days, the days before we got real pain killers? Oh, just like now, because you can’t get real pain killers any more because of some jackasses in congress stirring up shit for some kind of political game. My dentist won’t even write prescriptions for real pain meds any more because of all the paperwork involved. I am really beginning to hate the government.
Maybe I need to make friends with my local pusher. Medical insurance won’t cover the expense, but you can bet there won’t be any bureaucratic bullshit.
The rather minimal upside: the demand is still high, and there are enough manufacturers of the stuff to keep prices down around where they can be afforded by mere mortals, assuming said mortals can get a note from one of the gatekeepers. Out here we are blessed, or cursed, with facilities that specialize in outpatient treatment of chronic pain, or some comparable euphemism; each of them has a gatekeeper on staff.
Overuse of antibiotics has one well-known unfortunate consequence: the evolution of bacteria resistant to them. Vast quantities of antibiotics are used to dose up livestock and poultry, which doesn’t help matters at all. Fortunately, some fast-food name brands are about to shift to the undosed variety:
The parent company of Burger King and Tim Hortons, Restaurant Brands International Inc., has vowed to stop injecting chickens with antibiotics by the end of 2018.
Neither of these operations is famed for its chicken products, but this one is:
The company, which recently bought Popeye’s Louisiana Kitchen, said that the rule would apply to all brands under its umbrella.
Perdue and Tyson, the top two chicken processors, will be doing likewise, making it easier for the eateries to stick to their pledge.
Finding something wrong with the American health-care system, if “system” it be, is about as difficult as finding weeds in your next-door neighbor’s yard, especially since those weeds will eventually be in your yard. “Why can’t we do it like the Canadians do?” ask some people. Well, we could do worse, and pretty much any tweaking we do to our “system” will insure that we will do worse. Still, parking several billion dollars’ worth of bureaucrats throughout the chain will have similar results no matter whose flag they fly:
I’m curious: what must have happened to provoke the powers that be to make the health care system so inanely bureaucratic that wait times for life-saving surgeries are dramatically increased because of all the referrals for referrals required? Who could it possibly benefit?
I’ve written before about the system. After seeing an oncologist, to get a second visit to arrange to get a referral to a surgeon requires another referral to the oncologist from a family doctor. The same is true of many specialists.
We don’t necessarily do any better down here, and we have the additional complication of checking to see if anyone in the chain is Out Of Network, which will cost us a surcharge of somewhere between 20 percent and infinity.
Imagine the savings to the health care costs if, on the first visit to the oncologist, you were given your options WITH the names and numbers of various doctors to see depending on the decision you make, and then you were allowed to actually call them all by yourself! So once you decide to go with the hysterectomy before the mastectomy, then you DIRECTLY call the gynecologist!! That would be amazing!! But instead, it’s a bizarre, circuitous route from the family doctor to the oncologist to the family doctor to the oncologist (who says this should have been done months ago) and finally to whatever surgeon you need to save your own life.
Rules, rules, rules. And every bureaucracy worthy of the name has someone whose sole interest in life is insuring that all Ts are crossed, all Is are dotted, and no sentence ends with a period followed by two spaces. This is useful for a secondary-school English teacher; it’s not so useful for anyone in the health biz.
Californians will not be getting single-payer health care this year. Some of them are quite upset about that.
The proper response to the upjacking of the price of the EpiPen, courtesy of the FDA:
US regulators have approved new competition for EpiPen, the emergency allergy medicine that made Mylan a poster child for pharmaceutical company greed.
The Food and Drug Administration on Thursday approved Adamis Pharmaceuticals Corp.’s product, which should go on sale later this year.
Symjepi is a syringe prefilled with the hormone epinephrine, which helps stop life-threatening allergic reactions from insect stings and bites, foods such as nuts and eggs, or certain medications.
San Diego-based Adamis says its product is easier to use than Mylan’s EpiPen, a spring-loaded syringe filled with a set dose that comes with a training device.
Symjepi also is smaller than EpiPen, so it’s easier to fit in a pocket or purse.
Yes, but is it kinder to your wallet?
Adamis said it is still lining up a distributor so it hasn’t set the exact price for its product, which will be sold in pairs like EpiPen.
Adamis spokesman Mark Flather said Symjepi is intended to be a “low-cost alternative” to EpiPen and similar products, and the company is aiming to sell it for less than generic EpiPens.
We’ll have to keep an eye out for it.
VSG = vertical sleeve gastrectomy, the latest new wrinkle in bariatric (stomach-stapling) surgery. (I learn something every day.)
The “babies” cited will enter first grade and kindergarten this fall, so they’re not exactly infants. (Oh, the things you can be excited for. Me, I was excited by the sight of that Chick-Fil-A van.)
A chemical called sulforaphane, found in broccoli sprouts, has previously demonstrated an ability to reduce glucose levels in diabetic rats. Anders Rosengren of the University of Gothenburg in Sweden, and his colleagues wondered whether the same might be true for humans. To test the theory, his team gave 97 people with type 2 diabetes a concentrated dose of sulforaphane every day for three months, or a placebo. All but three people in the trial continued taking metformin. Those who didn’t take metformin were able to control their condition relatively well without it.
The concentration of sulforaphane given was around 100 times that found naturally in broccoli. “It was the same as eating around five kilograms of broccoli daily,” says Rosengren.
On average, those who received the broccoli extract saw their blood glucose reduce by 10 per cent more than those on the placebo. The extract was most effective in obese participants with “dysregulated” diabetes, whose baseline glucose levels were higher to start with.
“We’re very excited about the effects we’ve seen and are eager to bring the extract to patients,” says Rosengren. “We saw a reduction of glucose of about 10 per cent, which is sufficient to reduce complications in the eyes, kidneys and blood,” he says.
Besides, if you tried to eat 5 kg of broccoli, your intestines would be playing the opening to Also sprach Zarathustra.
Journal reference, should you need it: Science Translational Medicine, DOI: 10.1126/scitranslmed.aah4477.
In this brief clip, a young moose is freed from a stockade, kinda sorta:
Unharmed and happy. (Mynd you, møøse bites Kan be pretty nasti…)
Not everyone I’m likely to meet, I’ve discovered, is prepared to deal with someone who walks only with a bunch of equipment.